5-(2,5-dimethoxyphenyl)-1H-pyrazole-3-carboxylic acid
$300.00
CAS No.: 882238-14-4
Catalog No.: 196351
Purity: 95%
MF: C12H12N2O4
MW: 248.238
Storage: 2-8 degree Celsius
SMILES: COC1=C(C=C(C=C1)OC)C1=CC(=NN1)C(=O)O
Catalog No.: 196351
Purity: 95%
MF: C12H12N2O4
MW: 248.238
Storage: 2-8 degree Celsius
SMILES: COC1=C(C=C(C=C1)OC)C1=CC(=NN1)C(=O)O
CAS NO.: 882238-14-4; 5-(2,5-dimethoxyphenyl)-1H-pyrazole-3-carboxylic acid. PROPERTIES: This compound features a 5-(2,5-dimethoxyphenyl)-1H-pyrazole-3-carboxylic acid structure, combining a dimethoxyphenyl substituent and a pyrazole carboxylic acid group. It typically appears as a white to off-white crystalline solid with a molecular weight of approximately 239.2 g/mol (C12H11N2O4). The melting point ranges between 150-155°C, and it exhibits moderate solubility in common organic solvents like ethanol, methanol, and DMSO while being sparingly soluble in water. Proper storage requires a tightly sealed container in a cool, dry place. Safety considerations include wearing appropriate PPE. It is classified as a skin and eye irritant (GHS07) with the hazard statement H315-H319. APPLICATIONS: 5-(2,5-Dimethoxyphenyl)-1H-pyrazole-3-carboxylic acid serves as a versatile intermediate in pharmaceutical and chemical synthesis. Its 5-(2,5-dimethoxyphenyl)-1H-pyrazole-3-carboxylic acid structure allows for participation in various reactions, including esterification, amide bond formation, and nucleophilic substitution at the pyrazole ring. In medicinal chemistry, it is used to develop bioactive molecules targeting kinases, proteases, and G protein-coupled receptors. The dimethoxyphenyl group provides additional conjugation that enhances binding to biological targets. This compound also functions as a building block in the synthesis of fluorescent dyes and bioconjugation reagents. Academic studies employ it as a model compound in Medicinal Chemistry journals, focusing on optimizing the 5-(2,5-dimethoxyphenyl)-1H-pyrazole-3-carboxylic acid scaffold for improved biological activity and pharmacokinetic properties.
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